Novel and Bioactive Natural Products from the Marine-Derived Endophytic Fungi - Coniothyrium cereale, Phaeosphaeria spartinae and Auxarthron reticulatum
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منابع مشابه
HLE-inhibitory alkaloids with a polyketide skeleton from the marine-derived fungus Coniothyrium cereale.
The marine endophytic fungus Coniothyrium cereale produces the structurally unusual polyketide-type alkaloids (-)-cereolactam (1) and (-)-cereoaldomine (3), incorporating a lactam and an imine functionality, respectively, as well as the related metabolite (-)-trypethelone (2). Compounds 1 and 3 showed selective inhibition of human leukocyte elastase with IC50 values of 9.28 and 3.01 μM, respect...
متن کاملUnusual Nitrogenous Phenalenone Derivatives from the Marine-Derived Fungus Coniothyrium cereale.
The new phenalenone metabolites 1, 2, 4, and 6 were isolated from the marine-derived endophytic fungus Coniothyrium cereale, in addition to the ergostane-type sterol (3) and entatrovenetinone (5). Compounds 1 and 2 represent two unusual nitrogen-containing compounds, which are composed of a sterol portion condensed via two bonds to phenalenone derivatives. Compound 6, which contains unprecedent...
متن کاملSecondary Metabolites from the Marine Algal-Derived Endophytic Fungi: Chemical Diversity and Biological Activity.
Marine algal-derived endophytic fungi have attracted considerable attention in the most recent two decades due to their prolific production of structurally diverse secondary metabolites with various biological activities. This review summarizes a total of 182 natural products isolated from marine algal-derived endophytic fungi in the past two decades. The emphasis is on the unique chemical dive...
متن کاملPhenalenones: insight into the biosynthesis of polyketides from the marine alga-derived fungus Coniothyrium cereale.
The marine alga-derived fungus Coniothyrium cereale is a prolific producer of phenalenones. These polyketides were shown to possess antimicrobial effects and inhibitory activity towards the protease human leucocyte elastase (HLE). The current study focused on the biosynthesis of eight different structural types of phenalenones, comprising the natural products rousselianone A' (1), coniosclerodi...
متن کاملIsolation, identification and biodiversity of endophytic fungi o Thymus
Endophytes are considered as an important source of bioactive natural products because thesemicroorganisms are able to occupy unique biological niches and grow in non-ordinaryenvironments. Therefore, endophytic fungi of medicinal plants can be developed for medicinalapplications. On the other hand, medicinal properties of plant can be ascribed to its endophyticfungi. Thymus sp. is widely used a...
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تاریخ انتشار 2011